8 in 1 BioSerum




The 8-in-1 BioSerum is designed to deliver visible, targeted rejuvenation. As a biologically advanced serum concentrate, it features an unprecedented concentration of defensin molecules from the Age-Repair Defensin® Complex, affirming its position as a superior anti-aging serum.

Esteemed by dermatologists as an excellent retinol alternative, the 8-in-1 BioSerum serves as a premier rejuvenation serum, either alone or in combination with retinol or bakuchiol serums. Age-Repair Defensins®: Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of “fresh” and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.

Defensins are patented technology. The following list of DefenAge’s specific patents and patent applications:

+ Defensins for skin anti-aging: US 11,491,096, EP 3157504, EP 3586821.

+ Defensins for melasma: US 11,020,452, US 11,806,384, EP 15910892.


This innovative formula masterfully brings together the benefits of eight specialized serums:

+ Anti-Oxidants Serum: A robust blend of antioxidants, including Ergothioneine, combats environmental damage while brightening and energizing the skin.
+ Niacinamide Serum: Rich in high-performance Niacinamide (Vitamin B3), it soothes, hydrates, revitalizes the skin’s moisture barrier, and promotes a uniform skin tone.
+ Hyaluronic Acid (HA) Serum: Infused with low-weight Hyaluronic Acid for deep hydration, supplemented by a suite of intense moisturizers.
+ Collagen Serum: Enhanced with beta-defensin 3, the BioSerum boosts collagen, improves elasticity and firmness, and diminishes sagging.
+ Calming Serum: Contains Sea Whip extract, the sea’s most potent and swift anti- inflammatory agent, effectively addressing inflamm’aging.
+ Peptide Serum: A bespoke blend of peptides, including Palmitoyl Tripeptide-38, targets critical aging areas, smoothing wrinkles and refining skin texture.
+ DNA-Repair Enzyme Serum: Features enzymes from Mediterranean Arabidopsis, renowned for repairing common DNA damage.
+ Retinol-Alternative Serum: The crowning jewel of the 8-in-1 BioSerum is the highest concentration achievable of Alpha-Defensin 5—DefenAge’s exclusive and revolutionary ingredient. This bio-synthesized molecule marks a triumph in regenerative biology, renowned for its unparalleled ability to activate age-repair pathways, foster new skin development, and serve as a safe, highly effective alternative to retinol. The inclusion of Alpha-Defensin 5 represents not merely an advancement in skincare, but a paradigm shift in our approach to skin rejuvenation and anti-aging. The presence of this potent ingredient in the serum parallels the benefits of traditional retinol serums with a gentler approach, minimizing potential irritation and making it suitable for all skin types.


Apply twice daily. 30 seconds after 24/7 Barrier Balance Cream, place 1 pump of serum onto fingertips. While skin is still moist, lightly massage with fingertips first around eyes, then over entire face. Use a second pump on neck and decollete. In the AM, follow with sunscreen.


Water (Aqua), Cyclopentasiloxane, Glycerin, Niacinamide, Sinorhizobium Meliloti Ferment Filtrate, Dimethicone, Polysorbate 20, Dimethicone/Vinyl Dimethicone Crosspolymer, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Ammonium Acryloyldimethyltaurate/VP Copolymer, Phospholipids, Alpha-Defensin 5, Beta-Defensin 3, Palmitoyl Tripeptide-38, Sodium Hyaluronate, Arabidopsis Thaliana Extract, Sea Whip Extract, Ergothioneine, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Offinalis (Rosemary) Leaf Extract, Tocopheryl Acetate, Ubiquinone, Leuconostoc/Radish Root Ferment Filtrate, Albumin, L-Alanyl-L-Glutamine, Caprylic/Capric Triglyceride, Cetyl Hydroxyethylcellulose, Lecithin, Hydroxypropyl Cyclodextrin, Phytic Acid, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Sodium Chloride. Fragrance free.

This product does not contain retinol and should not be considered as a retinol serum.

Additional information

Weight 1 lbs
Dimensions 5.375 × 8.625 × 1.625 in


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